Figure 1. Multiscale model for Ca 2... | Rockefeller University Press

Figure 1.

Multiscale model for Ca2+sparks and waves in cardiomyocytes. (A) Arrangement of the RyR2 array in three concentric rings in the dyad cleft. (B) Side-on view of the spatial arrangement within a single voxel of the cytoplasm, the dyad cleft, the T-tubule, the TSR, and the RyR2 channels (not to scale). The Ca2+ diffusion/transport pathways between the compartments are indicated by blue arrows. (C) Arrangement of voxels that contain dyads and RyR2, associated with two representative planes of T-tubules. (D) Same arrangement shown within the model cell volume. The grids of T-tubules continue along the entire cell at 1.75-μm intervals. Refer to the image caption for details.

Multiscale model for Ca ²⁺ sparks and waves in cardiomyocytes. (A) Arrangement of the RyR2 array in three concentric rings in the dyad cleft. (B) Side-on view of the spatial arrangement within a single voxel of the cytoplasm, the dyad cleft, the T-tubule, the TSR, and the RyR2 channels (not to scale). The Ca²⁺ diffusion/transport pathways between the compartments are indicated by blue arrows. (C) Arrangement of voxels that contain dyads and RyR2, associated with two representative planes of T-tubules. (D) Same arrangement shown within the model cell volume. The grids of T-tubules continue along the entire cell at 1.75-μm intervals.