Figure 2.
Figure 2. Refer to the image caption for details.

Calcium-binding residues of dEsyt C2A domain are structurally similar to the hEsyt2 C2A domain. (A) Alignment of C2 domains from dEsyt (C2A-C), hEsyt2 (C2A-C), h-Synaptotagmin (C2A-B) and hEsyt1 (C2A-E). The residues important for binding calcium ions have been marked in red rectangles. (B) Alignment between hEsyt2 (Isoform B) and dEsyt C2A domain used for homology modeling using MODELLER. (C) Structural superposition of template hEsyt2 PDB ID 4npk and dEsyt model generated by MODELLER (RMSD = 0.159 Å). (D) MIB scores for residues of the wild type dEsyt protein. (E) Structural superposition of residues involved in calcium metal coordination. (F) MIB scores for residues of the mutant dEsyt protein.

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