RBM10-dependent CREBBP AS; RBM10 effects on NFκB transcriptional output. (A) Relative ratio of CREBBP exon 11 inclusion isoform determined by qRT-PCR in PE121410 and KTC1 cells ± RBM10. Data represent mean with SD of four replicates; statistical difference was analyzed by unpaired t test (***P < 0.0001). (B) NFκB activation score derived using a thyroid cancer–specific 50-gene signature (Cormier et al., 2023) in RBM10-null PE121410 and KTC1 cells versus their corresponding RBM10-expressing counterparts. Data represent mean with SEM.