Molecular features associated with RBM10 mutations. (A) Lollipop plot showing distribution and type of RBM10 mutations. Black: nonsense; green: missense mutations. (B) Oncoprint showing mutation frequency of RBM10 and the indicated drivers in the MSK clinical thyroid cancer cohort. (C) Oncoprint demonstrating co-occurrence of RBM10 mutations with MAPK pathway alterations. (D) Thyroid cancer histological characteristics in mice with the indicated genotypes over time; nd—not determined.