Figure 4. MLL3/GRHL2 co-regulate immune... | Rockefeller University Press

Figure 4.

$MLL3/GRHL2 co-regulate immune response genes. (A) A volcano plot of up- and downregulated genes from RNA-seq in MLL3 knockdown cells. Genes having binding peaks of MLL3 are marked as red dots, otherwise black dots. A similar volcano plot for GRHL2 knockdown is at the lower panel. (B) Bar graphs of the fraction of different groups of genes with binding peaks of MLL3 (left) or GRHL2 (right). (C) A Venn diagram illustrating shared downregulated genes between MLL3 knockdown and GRHL2 knockdown. A pie chart showing MLL3- and/or GRHL2-binding peaks on the 505 overlapped downregulated genes. (D) Top enriched signaling pathway of the 505 genes. (E) Gene set enrichment analysis (GSEA) plots showing the enrichment of IFN signaling in the RNA-seq upon knockdown of either MLL3 or GRHL2. P values were adjusted for multiple comparisons. Refer to the image caption for details.$

MLL3/GRHL2 co-regulate immune response genes. (A) A volcano plot of up- and downregulated genes from RNA-seq in MLL3 knockdown cells. Genes having binding peaks of MLL3 are marked as red dots, otherwise black dots. A similar volcano plot for GRHL2 knockdown is at the lower panel. (B) Bar graphs of the fraction of different groups of genes with binding peaks of MLL3 (left) or GRHL2 (right). (C) A Venn diagram illustrating shared downregulated genes between MLL3 knockdown and GRHL2 knockdown. A pie chart showing MLL3- and/or GRHL2-binding peaks on the 505 overlapped downregulated genes. (D) Top enriched signaling pathway of the 505 genes. (E) Gene set enrichment analysis (GSEA) plots showing the enrichment of IFN signaling in the RNA-seq upon knockdown of either MLL3 or GRHL2. P values were adjusted for multiple comparisons.