Figure S3.
Reduced MHC-II expression in microglia of Atg7ΔMG-5xFAD mice. (A) Violin plots showing the module scores of gene set antigen processing and presentation. ns = not significant; ****, P < 0.0001 calculated by stat_compare_means function in ggpubr package. (B) Left: Representative confocal images showing MHC-II, IBA1, and Methoxy-X04 staining in the cortex of 5-mo-old Atg7fl/fl-5xFAD and Atg7ΔMG-5xFAD mice; scale bar = 100 μm. Right: Quantification of the ratio between MHC-II+IBA1+ voxels and IBA1+ voxels. Each data point represents one mouse with three technical repeats. **, P < 0.01 by unpaired t test. Data are presented as mean ± SEM. Refer to the image caption for details.

Reduced MHC-II expression in microglia of Atg7 ΔMG -5xFAD mice. (A) Violin plots showing the module scores of gene set antigen processing and presentation. ns = not significant; ****, P < 0.0001 calculated by stat_compare_means function in ggpubr package. (B) Left: Representative confocal images showing MHC-II, IBA1, and Methoxy-X04 staining in the cortex of 5-mo-old Atg7fl/fl-5xFAD and Atg7ΔMG-5xFAD mice; scale bar = 100 μm. Right: Quantification of the ratio between MHC-II+IBA1+ voxels and IBA1+ voxels. Each data point represents one mouse with three technical repeats. **, P < 0.01 by unpaired t test. Data are presented as mean ± SEM.

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