Figure S5.
Comparative interactions between NBR1 and LC3, FIP200Claw, and TAX1BP1CC2. (A) Predictive structural model of NBR1725–749 with FIP200Claw. Model was generated using AlphaFold AF2-multimer with MMseqs2 through Google Colab. TIR inset shows no meaningful interactions. (B) LIR inset from A, highlighting core LIR residues (NBR1Y732 and NBR1I735) and the interaction between NBR1D731 and NBR1E730 with FIP200R1573 and FIP200K1569, respectively. (C) Predicted IDDT per position (pLDDT) for NBR1725–749 in complex with FIP200Claw. Blue is high confidence; red is low confidence. (D) Predictive structural model of NBR1725–749 with MAP1LC3A. The model was generated using AlphaFold AF2-multimer with MMseqs2 through Google Colab. TIR inset shows no meaningful interactions. (E) LIR inset from D, highlighting core LIR residues (NBR1Y732 and NBR1I735) and NBR1D731 and NBR1E730. (F) Predicted IDDT per position (pLDDT) for NBR1725–749 in complex with MAP1LC3A. Blue is high confidence; red is low confidence. (G) Buried surface area (BSA) analysis using the PDBePISA server of NBR1725–749 with MAP1LC3A, FIP200Claw, and TAX1BP1CC2. NBR1 residues spanning 727–747 are shown. Refer to the image caption for details.

Comparative interactions between NBR1 and LC3, FIP200 Claw , and TAX1BP1 CC2 . (A) Predictive structural model of NBR1725–749 with FIP200Claw. Model was generated using AlphaFold AF2-multimer with MMseqs2 through Google Colab. TIR inset shows no meaningful interactions. (B) LIR inset from A, highlighting core LIR residues (NBR1Y732 and NBR1I735) and the interaction between NBR1D731 and NBR1E730 with FIP200R1573 and FIP200K1569, respectively. (C) Predicted IDDT per position (pLDDT) for NBR1725–749 in complex with FIP200Claw. Blue is high confidence; red is low confidence. (D) Predictive structural model of NBR1725–749 with MAP1LC3A. The model was generated using AlphaFold AF2-multimer with MMseqs2 through Google Colab. TIR inset shows no meaningful interactions. (E) LIR inset from D, highlighting core LIR residues (NBR1Y732 and NBR1I735) and NBR1D731 and NBR1E730. (F) Predicted IDDT per position (pLDDT) for NBR1725–749 in complex with MAP1LC3A. Blue is high confidence; red is low confidence. (G) Buried surface area (BSA) analysis using the PDBePISA server of NBR1725–749 with MAP1LC3A, FIP200Claw, and TAX1BP1CC2. NBR1 residues spanning 727–747 are shown.

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