Flicker ERG at high frequency of Ptf1aCREconditional Fat3 mice (Ptf1acKO). (A) Schematic representation of cell classes that express FAT3 in wild type retina, shown in magenta. (B) Schematic representation of cell classes, i.e., ACs, that lose Fat3 expression in a Ptf1acKO, shown in black outlines. (C) Flicker ERG amplitude at 0.5, 10, 20, 30, 40, and 50 Hz for the Ptf1acKO condition. Control exact genotypes are Ptf1aCRE;Fat3fl/+ (n = 8 eyes) and Ptf1acKO exact genotypes are Ptf1aCRE;Fat3fl/∆TM (n = 8 eyes). Unpaired two-tailed Student’s t test. Error bar: SEM. (D) Flicker ERG implicit time at 20 Hz for control (39.0 ± 0.4 ms, n = 8 eyes) and Ptf1acKO (38.9 ± 1.0 ms, n = 8 eyes). Unpaired two-tailed Student’s t test. Error bar: SEM. (E) Representative flicker ERG raw traces for control (n = 8 eyes) and Ptf1acKO (n = 8 eyes).
Figure 2.

Flicker ERG at high frequency of Ptf1a CRE conditional Fat3 mice (Ptf1a cKO ). (A) Schematic representation of cell classes that express FAT3 in wild type retina, shown in magenta. (B) Schematic representation of cell classes, i.e., ACs, that lose Fat3 expression in a Ptf1acKO, shown in black outlines. (C) Flicker ERG amplitude at 0.5, 10, 20, 30, 40, and 50 Hz for the Ptf1acKO condition. Control exact genotypes are Ptf1aCRE;Fat3fl/+ (n = 8 eyes) and Ptf1acKO exact genotypes are Ptf1aCRE;Fat3fl/∆TM (n = 8 eyes). Unpaired two-tailed Student’s t test. Error bar: SEM. (D) Flicker ERG implicit time at 20 Hz for control (39.0 ± 0.4 ms, n = 8 eyes) and Ptf1acKO (38.9 ± 1.0 ms, n = 8 eyes). Unpaired two-tailed Student’s t test. Error bar: SEM. (E) Representative flicker ERG raw traces for control (n = 8 eyes) and Ptf1acKO (n = 8 eyes).

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