Figure 2.
Distinct voltage dependencies of NaP and gating pore current cause depolarization of Vm in 3.5 mM K+in hypoKPP, but not hyperKPP. (A) Animal averages of EDL resting potentials in mouse EDL muscle at 3.5 mM K+ (35°C) for WT, hypoKPP, and hyperKPP. Mean values for Vm ± SD in mV were −83.3 ± 3.0 for WT hypoKPP, −75.0 ± 2.5 for hypoKPP, −81.1 ± 2.5 for WT hyperKPP, and −79.8 ± 4.0 for hyperKPP. N = 40 fibers from 4 mice for WT hypoKPP, 40 fibers from 4 mice for hypoKPP, 51 fibers from 10 WT hyperKPP, and 35 fibers from 7 hyperKPP. ** indicates P = 3 × 10−4. WT hyperKPP versus hyperKPP P = 0.36. WT hypoKPP are WT mice from the colony of hypoKPP mice and WT hyperKPP are WT mice from the colony of hyperKPP mice. (B) Current–voltage relationships of the gating pore current and NaP used in simulations. Refer to the image caption for details.

Distinct voltage dependencies of NaP and gating pore current cause depolarization of Vm in 3.5 mM K + in hypoKPP, but not hyperKPP. (A) Animal averages of EDL resting potentials in mouse EDL muscle at 3.5 mM K+ (35°C) for WT, hypoKPP, and hyperKPP. Mean values for Vm ± SD in mV were −83.3 ± 3.0 for WT hypoKPP, −75.0 ± 2.5 for hypoKPP, −81.1 ± 2.5 for WT hyperKPP, and −79.8 ± 4.0 for hyperKPP. N = 40 fibers from 4 mice for WT hypoKPP, 40 fibers from 4 mice for hypoKPP, 51 fibers from 10 WT hyperKPP, and 35 fibers from 7 hyperKPP. ** indicates P = 3 × 10−4. WT hyperKPP versus hyperKPP P = 0.36. WT hypoKPP are WT mice from the colony of hypoKPP mice and WT hyperKPP are WT mice from the colony of hyperKPP mice. (B) Current–voltage relationships of the gating pore current and NaP used in simulations.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal