Figure 3. Cd34 cells generated... | Rockefeller University Press

Figure 3.

Cd34+cells generated myofibroblasts during periportal fibrosis and CAFs in ICC. (A, B, D, and F) Confocal images of liver sections from normal (A), CCl4-treated (B), DDC-treated (D), and ICC-bearing (F) Cd34creER;R26tdTomato mice, stained with DAPI and anti-Col1 antibody. Scale bar = 200 µm (n = 5 mice per condition from three independent experiments). (C, E, and G) Quantification of the percentage of Col1+ cells that were Tomato+ in CCl4-treated (C), DDC-treated (E), and ICC-bearing (G) Cd34creER;R26tdTomato mice. Data represent the mean ± SD. Refer to the image caption for details.

Cd34 ⁺ cells generated myofibroblasts during periportal fibrosis and CAFs in ICC. (A, B, D, and F) Confocal images of liver sections from normal (A), CCl₄-treated (B), DDC-treated (D), and ICC-bearing (F) Cd34^creER;R26^tdTomato mice, stained with DAPI and anti-Col1 antibody. Scale bar = 200 µm (n = 5 mice per condition from three independent experiments). (C, E, and G) Quantification of the percentage of Col1⁺ cells that were Tomato⁺ in CCl₄-treated (C), DDC-treated (E), and ICC-bearing (G) Cd34^creER;R26^tdTomato mice. Data represent the mean ± SD.