Overlap between responses to Type-I interferon and inflammatory cytokines. (A) Interferon signature genes are highlighted in red on volcano plots depicting responses to TNFα in a representative subset of cell types. The numbers of ISG up- or downregulated are shown, with the chi square P value of the distribution (−log₁₀). (B) ISG regulatory network, depicting the control of individual ISGs (in columns) by TFs (in row). Clusters 1–5 group ISGs with different regulatory modes, which also correspond to different functional groups (reprinted from Mostafavi et al. [2016]). (C) Genes from each of the clusters defined in B are highlighted on volcano plots of peritoneal macrophages (MF.PC) (top row) and naive CD4⁺ T cells (T4n) (bottom) treated with IL1β.