Overlap between responses to inflammatory and γc cytokines. (A) Simple counting of overlap: tables at left show, for each cell type, the raw number of genes with FoldChange >2 and P value <0.01 (after either IL1β or TNFα treatment, data from Fig. 1) and are also induced by greater than twofold by one of the γc cytokines (bottom tables, same for repressed transcripts). The table in right have the same values, as the percentage of IL1β/TNFα affected genes. (B) FoldChange/FoldChange plot comparing effects of TNFα and IL2 in natural killer (NK) cells. (C) FoldChange/FoldChange plot of the effects of IL1β and IL6 in regulatory T cells (Tregs). Transcripts induced or repressed by IL2 in Tregs are highlighted in orange and blue, respectively. (D) FoldChange/FoldChange plot of the effects of IL4 and TNFα in monocytes (Mo). Myc target genes (MSigDB Hallmark) are highlighted in red. (E) Heatmap comparison of responses to inflammatory and γc cytokines. Genes and clustering are as selected and clustered in Fig. 1 B (reproduced at left for comparison). The membership of these genes among γc response clusters is shown in the right half (clusters from Baysoy et al. [2023]), upregulated clusters in red, downregulated clusters in blue). (F) String database representation of all transcripts shared between responses to γc and inflammatory cytokines, color-coded by Gene Ontology as indicated.