Cell-type specificity of responses. (A) Sharing of transcripts responsive to TNFa, IL6, or IL1b, computed as the Jaccard index between signature lists (at a FoldChange >1.5 threshold), ×100 for clarity. (B) Paired volcano plots comparing responses to IL1β in peritoneal macrophages (MF.PC) versus monocytes (Mo) (left) or natural killer (NK) cells versus CD8⁺ T cells (T8em) (right). Genes that meet FoldChange >2 or <0.5 with a P value <0.01 in MF.PC are highlighted in red or blue on the Mo plot; the number of genes with FoldChange <1 or >1 is shown in the corresponding quadrant, denoting the biased distribution (and the same for NK and T8em). (C) Top row: FoldChange/FoldChange plots comparing responses to TNFα in naive CD4⁺ T cells (T4n) (all x-axes) versus other cell types on the y-axis: neutrophils (GN), Mo, CD8⁺ dendritic cells (DC8), follicular B cells (Bfo), NK, and regulatory T cells (Tregs). Bottom row: same comparisons versus MF.PC on the x-axis. (D) FoldChange/FoldChange plot comparing effects of IL1β in T4n and in Tregs. Color-coded by P value as per Fig. 5.