Potential correlations between drug promiscuity/percentage of pore occupancy and physiochemical/pharmacokinetic properties. (A–F) Values are plotted from Table 2, with trend lines shown for relationships where Pearson correlation coefficient, r < −0.6, r > 0.6 (i.e., the correlation values highlighted in bold in Table 2). Each panel shows the pairwise comparison between (A) molecular weight of the drugs and percentage of pore occupancy/promiscuity of neutral versions only; (B) octanol-water partition coefficient (LogP) and promiscuity; (C) number of rotatable bonds and percentage of pore occupancy; (D) IC50 and promiscuity; (E) promiscuity and association/dissociation kinetics; (F) promiscuity of neutral versions of each drug and affinity to the inactivated state of Nav.