Residue interactions were identified across the top five clusters of each drug. (A) Summary bar chart showing the most common interacting residues identified for all drugs, showing residues where total occupancy >50% for at least one of the drugs. (B) Locations of each of the residues in panel A shown on the S5/S6/P-loop of the four domains. (C) Stacked bar chart of the number of interacting residues categorized into the different interaction types.