Figure 6. Voltage-activated SR Ca 2... | Rockefeller University Press

Figure 6.

Voltage-activated SR Ca2+release in WT and DMDmdxmuscle fibers. (A) Examples of confocal line-scan images of rhod-2 fluorescence collected from a WT and from a DMDmdx muscle fiber, while applying a depolarizing pulse to −10 mV. (B) Line-averaged rhod-2 fluorescence changes elicited by the pulses shown on top, in the same WT and DMDmdx fibers as in A. (C) Rate of SR Ca2+ release calculated from the rhod-2 F/F0 records shown in B. (D) Running integral of the SR Ca2+ flux traces shown in C during the depolarizing pulses. Refer to the image caption for details.

Voltage-activated SR Ca ²⁺ release in WT and DMD ^mdx muscle fibers. (A) Examples of confocal line-scan images of rhod-2 fluorescence collected from a WT and from a DMD^mdx muscle fiber, while applying a depolarizing pulse to −10 mV. (B) Line-averaged rhod-2 fluorescence changes elicited by the pulses shown on top, in the same WT and DMD^mdx fibers as in A. (C) Rate of SR Ca²⁺ release calculated from the rhod-2 F/F₀ records shown in B. (D) Running integral of the SR Ca²⁺ flux traces shown in C during the depolarizing pulses.