The balance of vacuolar acidification and PI(3,5)P2 levels between mother and newborn daughter cells changes during the yeast cell cycle. Top: A daughter cell buds from the mother, which transfers vacuoles at a defined point in the cell cycle. At this point, the mother vacuole is acidified (light pink) and vacuolar levels of PI(3,5)P2 (purple) are relatively low. Right: In early anaphase, pronounced asymmetry between the mother and daughter vacuoles emerges. The daughter vacuole exhibits high levels of PI(3,5)P2 and becomes more acidic (dark pink) than the mother vacuole, which is transiently alkalinized (blue). Bottom left: After cell division, PI(3,5)P2 asymmetry disappears and both mother and daughter vacuoles are acidified.
Figure 1.

The balance of vacuolar acidification and PI(3,5)P 2 levels between mother and newborn daughter cells changes during the yeast cell cycle. Top: A daughter cell buds from the mother, which transfers vacuoles at a defined point in the cell cycle. At this point, the mother vacuole is acidified (light pink) and vacuolar levels of PI(3,5)P2 (purple) are relatively low. Right: In early anaphase, pronounced asymmetry between the mother and daughter vacuoles emerges. The daughter vacuole exhibits high levels of PI(3,5)P2 and becomes more acidic (dark pink) than the mother vacuole, which is transiently alkalinized (blue). Bottom left: After cell division, PI(3,5)P2 asymmetry disappears and both mother and daughter vacuoles are acidified.

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