Function of IFNAR1 variants in the patients’ fibroblasts. (A) Intracellular FACS staining of phosphorylated STAT1 in SV40 fibroblasts stimulated with IFN-α8 (1,000 U/ml) or IFN-α8 (1,000 U/ml) for 15 min for two healthy controls and patients. (B) Intracellular FACS staining of phosphorylated STAT1 in primary fibroblasts stimulated with IFN-α2a (1,000 U/ml), IFN-ω (1 ng/ml), IFN-β (50, 100, and 100 U/ml), or IFN-γ (1,000 U/ml) for 15 min, for two healthy controls and patients. The graphs show representative data from two independent experiments.
Figure S3.

Function of IFNAR1 variants in the patients’ fibroblasts. (A) Intracellular FACS staining of phosphorylated STAT1 in SV40 fibroblasts stimulated with IFN-α8 (1,000 U/ml) or IFN-α8 (1,000 U/ml) for 15 min for two healthy controls and patients. (B) Intracellular FACS staining of phosphorylated STAT1 in primary fibroblasts stimulated with IFN-α2a (1,000 U/ml), IFN-ω (1 ng/ml), IFN-β (50, 100, and 100 U/ml), or IFN-γ (1,000 U/ml) for 15 min, for two healthy controls and patients. The graphs show representative data from two independent experiments.

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