Model for PLK-mediated regulation of SC assembly and disassembly via phosphorylation of SYP-5/6 C-termini in C. elegans. (A) PLK-dependent phosphorylation of the C-termini of SYP-5/6 occurs just prior to meiotic entry. (B) Localized phosphorylation of SYP-5/6 by PLKs at the pairing centers links homolog pairing with the initiation of synapsis. (C) Phosphorylation of the SYP-5/6 C-termini establishes an electrostatic interface between chromosome axes and the central region of the SC, facilitated by cation–anion and π interactions. The structural model of phosphorylated SYP-5 was generated using AlphaFold3. (D) Phosphorylation of SYP-5/6 by PLKs reinforces the SC short-arm identity, ensuring accurate segregation of holocentric chromosomes during meiosis I.
Figure 7.

Model for PLK-mediated regulation of SC assembly and disassembly via phosphorylation of SYP-5/6 C-termini in C. elegans. (A) PLK-dependent phosphorylation of the C-termini of SYP-5/6 occurs just prior to meiotic entry. (B) Localized phosphorylation of SYP-5/6 by PLKs at the pairing centers links homolog pairing with the initiation of synapsis. (C) Phosphorylation of the SYP-5/6 C-termini establishes an electrostatic interface between chromosome axes and the central region of the SC, facilitated by cation–anion and π interactions. The structural model of phosphorylated SYP-5 was generated using AlphaFold3. (D) Phosphorylation of SYP-5/6 by PLKs reinforces the SC short-arm identity, ensuring accurate segregation of holocentric chromosomes during meiosis I.

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