Putative trans interactions between Na _V 1.5/β1 complexes. (A and B) Full snapshots (A) and close-up (B) image of the “tip-to-tip” models of the trans interactions between Na_V1.5/β1 complexes on opposing membranes (grey). (C and D) Full snapshots and (D) close-up image of the “side-to-side” models. Note the potential for glycan hindrance in the side-to-side model.