Figure 4.
N-linked glycan density on NaV1.4 and NaV1.5. Images show overlapping and superimposed snapshots of glycan conformations extracted from the molecular dynamics simulations every 5 ns, over a time frame of 150 ns. (A) Top view of NaV1.4. (B and C) Side views of NaV1.4, VSDs IV and II, respectively. (D) Top view of NaV1.5. (E and F) Side views of NaV1.5, VSDs IV and II, respectively. Glycans interacting with VSD IV are depicted. The NaV1.4 (C) and NaV1.5 (F) glycans interacting near VSD II are displayed. Glycans are shown in dark gold, with sialylated tips in red.

N-linked glycan density on Na V 1.4 and Na V 1.5. Images show overlapping and superimposed snapshots of glycan conformations extracted from the molecular dynamics simulations every 5 ns, over a time frame of 150 ns. (A) Top view of NaV1.4. (B and C) Side views of NaV1.4, VSDs IV and II, respectively. (D) Top view of NaV1.5. (E and F) Side views of NaV1.5, VSDs IV and II, respectively. Glycans interacting with VSD IV are depicted. The NaV1.4 (C) and NaV1.5 (F) glycans interacting near VSD II are displayed. Glycans are shown in dark gold, with sialylated tips in red.

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