Enr ichment in pDC subsets with high IFN-I signature in SSc patients. (A) UMAP plots of five SCs of pDCs (n = 9,885 cells). (B) A heat map representing scaled expression values of the top five genes defining each SC of pDCs. (C) Bar plots highlighting the percentage of the cell number of HDs and SSc patients in each SC of pDCs. (D) UMAP plots of SCs of pDCs split by healthy (n = 4,414 cells) and SSc donors (n = 5,471 cells). (E) UMAP plot showing the ISGs score in pDCs. (F) The comparison of ISGs score of each SC of pDCs. (G and H) The trajectory analysis of pDCs. (I and J) The UMAP plot shows the trajectory of the pseudotime score in the pDCs of healthy donors and SSc patients, as indicated.