Figure 2. Effects of FKBP12 deficiency... | Rockefeller University Press

$Effects of FKBP12 deficiency on cardiac function in male and female mice. (A, E, I, and M) Ejection fraction (EF) for 3-mo-old male, 6-mo-old male, 3-mo-old female, and 6-mo-old female mice, respectively. (B, F, J, and N) Fractional shortening (FS) for 3-mo-old male, 6-mo-old male, 3-mo-old female, and 6-mo-old female mice, respectively. (C, G, K, and O) Left ventricular interior dimension in diastole (LVIDd) for 3-mo-old male, 6-mo-old male, 3-mo-old female, and 6-mo-old female mice, respectively. (D, H, L, and P) Left ventricular anterior wall thickness during systole (LVAWs) for 3-mo-old male, 6-mo-old male, 3-mo-old female, and 6-mo-old female mice, respectively. 3-mo-old male mice: n = 13 for FL, n = 7 for MCK-FKD, n = 15 for MHC-Cre+, and n = 17 for MHC-FKD. For 6-mo-old male mice: n = 11 for FL, n = 8 for MCK-FKD, n = 8 for MHC-Cre+, and n = 7 for MHC-FKD. For 3-mo-old female mice: n = 16 for FL, n = 10 for MCK-FKD, n = 13 for MHC-Cre+, and n = 13 for MHC-FKD. For 6-mo-old female mice: n = 10 for FL, n = 5 for MCK-FKD, n = 10 for MHC-Cre+, and n = 14 for MHC-FKD. Data were analyzed by one-way ANOVAs and P value indicated. Data are shown as mean ± SD.$

Figure 2.

Effects of FKBP12 deficiency on cardiac function in male and female mice. (A, E, I, and M) Ejection fraction (EF) for 3-mo-old male, 6-mo-old male, 3-mo-old female, and 6-mo-old female mice, respectively. (B, F, J, and N) Fractional shortening (FS) for 3-mo-old male, 6-mo-old male, 3-mo-old female, and 6-mo-old female mice, respectively. (C, G, K, and O) Left ventricular interior dimension in diastole (LVIDd) for 3-mo-old male, 6-mo-old male, 3-mo-old female, and 6-mo-old female mice, respectively. (D, H, L, and P) Left ventricular anterior wall thickness during systole (LVAWs) for 3-mo-old male, 6-mo-old male, 3-mo-old female, and 6-mo-old female mice, respectively. 3-mo-old male mice: n = 13 for FL, n = 7 for MCK-FKD, n = 15 for MHC-Cre⁺, and n = 17 for MHC-FKD. For 6-mo-old male mice: n = 11 for FL, n = 8 for MCK-FKD, n = 8 for MHC-Cre⁺, and n = 7 for MHC-FKD. For 3-mo-old female mice: n = 16 for FL, n = 10 for MCK-FKD, n = 13 for MHC-Cre⁺, and n = 13 for MHC-FKD. For 6-mo-old female mice: n = 10 for FL, n = 5 for MCK-FKD, n = 10 for MHC-Cre⁺, and n = 14 for MHC-FKD. Data were analyzed by one-way ANOVAs and P value indicated. Data are shown as mean ± SD.

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