Figure 6.
TGFβ-producing TANs are enriched in MASH-related HCC patients. (A) NicheNet analysis of HCC patient dataset (https://ngdc.cncb.ac.cn/bioproject/browse/PRJCA007744). Prioritized ligands from neutrophils, and their target genes, driving transcriptomic differences in tumor cells between patients with high or low neutrophil infiltration. (B) Distributions of TAN-derived TGFβ production signature in HCC patients with non-MASH (GSE63898) and MASH (GSE164760) etiologies. (C) Representative immunofluorescence images and quantification of TGFβ-producing CD66b+neutrophils (CD66b: red; TGFβ: green; nucleus: blue) among all neutrophils in tumors resected from patients with HBV-related HCC or MASH-related HCC. Scale bars represent 50 and 20 μm. Each symbol represents one patient (C). Data is mean ± SEM. **P < 0.01 by Wilcoxon rank-sum test (B) and unpaired Student’s t test (C).

TGFβ-producing TANs are enriched in MASH-related HCC patients. (A) NicheNet analysis of HCC patient dataset (https://ngdc.cncb.ac.cn/bioproject/browse/PRJCA007744). Prioritized ligands from neutrophils, and their target genes, driving transcriptomic differences in tumor cells between patients with high or low neutrophil infiltration. (B) Distributions of TAN-derived TGFβ production signature in HCC patients with non-MASH (GSE63898) and MASH (GSE164760) etiologies. (C) Representative immunofluorescence images and quantification of TGFβ-producing CD66b+neutrophils (CD66b: red; TGFβ: green; nucleus: blue) among all neutrophils in tumors resected from patients with HBV-related HCC or MASH-related HCC. Scale bars represent 50 and 20 μm. Each symbol represents one patient (C). Data is mean ± SEM. **P < 0.01 by Wilcoxon rank-sum test (B) and unpaired Student’s t test (C).

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