Points of possible intervention. There are several points of possible intervention prior to the development of aggressive and often difficult-to-treat malignancies. The first point of possible intervention is in those with premalignant CH and includes improved screening for CH in the outpatient and primary care setting as well as dedicated clinics for laboratory surveillance, age-appropriate cancer screening, and risk reduction via lifestyle modifications. Additionally, further studies are needed regarding the efficacy of anti-inflammatory drugs and targeted therapies for preventing malignant transformation in those with premalignant CH. The second point of possible intervention is in those with a primary malignancy. We argue that CH status should be implemented in treatment decision pathways, such as the use of adjunctive chemotherapy in those with localized disease, as this may help mitigate the risk of future t-MNs in those with underlying CH. Created in BioRender. Franco, S. (2024) https://BioRender.com/a12g213.