The effects of histamine on responses to GABA in the β3(Q64R+G127T) receptor. (A) Concentration–response relationship for histamine. The data points give means ± SD from six cells. The solid line was calculated using the averaged fitting results (EC50 = 9 mM, nHill = 1.45, and Ymax = 0.50). (B) Response ratios as a function of PA,GABA. The experiments were done in the presence of 1 or 2 mM histamine. The lines show linear fits with the RR = 1 intercept at 0.33 ± 0.04 at 1 mM histamine and 0.51 ± 0.12 at 2 mM histamine. The arrow in panel B indicates the value of PA,max (0.50) for histamine estimated from the high-concentration asymptote in panel A.
Figure 3.

The effects of histamine on responses to GABA in the β3(Q64R+G127T) receptor. (A) Concentration–response relationship for histamine. The data points give means ± SD from six cells. The solid line was calculated using the averaged fitting results (EC50 = 9 mM, nHill = 1.45, and Ymax = 0.50). (B) Response ratios as a function of PA,GABA. The experiments were done in the presence of 1 or 2 mM histamine. The lines show linear fits with the RR = 1 intercept at 0.33 ± 0.04 at 1 mM histamine and 0.51 ± 0.12 at 2 mM histamine. The arrow in panel B indicates the value of PA,max (0.50) for histamine estimated from the high-concentration asymptote in panel A.

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