Proposed role of BTNL8 in MIS-C. Schematic diagram of proposed mechanism of BTNL8 contribution to MIS-C. Upon infection with SARS-CoV-2, BTNL8 variants are unable to effectively engage with Vγ4⁺γδ T cells contributing to underlying intestinal inflammation subsequently leading to a hyperinflammatory state. Image created with https://BioRender.com.