Molecular characterization of BTNL8 variants in MIS-C. (A) Schematic representation of BTNL8 depicting location of identified variants. Variants with impairment indicated in red on schematic diagram. (B) CADD score (GRch17-v1.6) versus AF of all BTNL8 variants (<1% AF) identified. (C) Lolliplot of BTNL8 variants identified within the MIS-C and COVID-19 cohorts depicting global AF and location within the protein. p.P299L included as the variant meets the 1% cut off for several relevant ancestral groups. Images created with https://BioRender.com.