Comparison of activation efficiency of different human NMDARs. (A) Mean (±SEM) success rate: *P < 0.05, **P < 0.01, ****P < 0.0001, one-way ANOVA (P < 0.0001) with a post-hoc Tukey’s test: N2A versus N2B, P = 0.0036, N2A versus N2C, P = 0.03, N2A versus N2D, P = 0.045; N2B versus N2C, P < 0.0001, N2B versus N2D, P < 0.0001; N2C versus N2D, P = 0.99. (B) Mean (±SEM) efficiency (η) of activation: ****P < 0.0001, one-way ANOVA (P < 0.0001) with a post-hoc Tukey’s test: N2A versus N2B, P < 0.0001, N2A versus N2C, P = 0.44, N2A versus N2D, P = 0.58; N2B versus N2C, P < 0.0001, N2B versus N2D, P < 0.0001; N2C versus N2D, P > 0.99. (C) Mean (±SEM) average latency: ****P < 0.0001, one-way ANOVA (P < 0.0001) with a post-hoc Tukey’s test: N2A versus N2B, P < 0.0001, N2A versus N2C, P = 0.70, N2A versus N2D, P = 0.81; N2B versus N2C, P < 0.0001, N2B versus N2D, P = 0.0008; N2C versus N2D, P > 0.99. See Table 2 for additional details. Note that “not significant” comparisons are not indicated.