Figure 6.
Activation of presumed triheteromeric GluN2A and GluN2B receptors. (A and B) Currents from a patch containing a single presumed GluN1/GluN2A/GluN2B receptor in response to 1-s glutamate applications. See Table 4 for additional details. (C) Dwell time histogram of the latency to first opening for presumed triheteromeric receptors. The histogram was best fit by a single exponential (solid line). (D and E) Mean (±SEM) efficiency (η) of activation (D) or average latency (E) for diheteromeric GluN1/GluN2A or GluN1/GluN2B receptors or triheteromeric GluN1/GluN2A/GluN2B receptors. (D) ****P < 0.0001, one-way ANOVA (P < 0.0001) with a post-hoc Tukey’s test: N2A versus N2B, P < 0.0001; N2A versus N2A/N2B, P = 0.84, N2B versus N2A/N2B, P < 0.0001. (E) ****P < 0.0001, one-way ANOVA (P < 0.0001) with a post-hoc Tukey’s test: N2A versus N2B, P < 0.0001; N2A versus N2A/N2B, P = 0.99, N2B versus N2A/N2B, P < 0.0012. h, human.

Activation of presumed triheteromeric GluN2A and GluN2B receptors. (A and B) Currents from a patch containing a single presumed GluN1/GluN2A/GluN2B receptor in response to 1-s glutamate applications. See Table 4 for additional details. (C) Dwell time histogram of the latency to first opening for presumed triheteromeric receptors. The histogram was best fit by a single exponential (solid line). (D and E) Mean (±SEM) efficiency (η) of activation (D) or average latency (E) for diheteromeric GluN1/GluN2A or GluN1/GluN2B receptors or triheteromeric GluN1/GluN2A/GluN2B receptors. (D) ****P < 0.0001, one-way ANOVA (P < 0.0001) with a post-hoc Tukey’s test: N2A versus N2B, P < 0.0001; N2A versus N2A/N2B, P = 0.84, N2B versus N2A/N2B, P < 0.0001. (E) ****P < 0.0001, one-way ANOVA (P < 0.0001) with a post-hoc Tukey’s test: N2A versus N2B, P < 0.0001; N2A versus N2A/N2B, P = 0.99, N2B versus N2A/N2B, P < 0.0012. h, human.

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