Distribution of response groups of CLL cells treated with the three different JNK1 inhibitors SP600125 CC-930 or the peptide inhibitor L-JNKi. Sensitivity to the inhibitors was defined as IC50 below 2 µM to the kinase inhibitors and below 3 µM to the peptide inhibitor JNK1i. In the responsive group, the CLL sample was sensitive to all three inhibitors, in the intermediate responsive group the CLL sample was sensitive to 1–2 inhibitors, and in the resistant group, the CLL sample did not respond to any JNK1 inhibitor. IC50 values were determined after 24 h of inhibitor treatment.