Figure 7. Simulations varying N , using... | Rockefeller University Press

Figure 7.

Simulations varying N, using v = 50 s−1and κsys= 2 pN/nm. (A–H) Left panels are simulated time courses of force, F, ergodicity, a (inset), and right panels are F and NMDP replotted and overlaid with Eqs. 1 (blue curve) and 2 (red curve) using N values of (A and B) 5, (C and D) 15, (E and F) 30, and (G and H) 100. In these simulations, ∆Go = −5.7 RT and d = 8 nm which according to Eq. 2 gives Fo= −N∆Go/d = 3N pN when NAMD = NMDP. The simulated time courses of state occupancies are in Fig. S5.

Simulations varying N, using v = 50 s ⁻¹ and κ _sys = 2 pN/nm. (A–H) Left panels are simulated time courses of force, F, ergodicity, a (inset), and right panels are F and N_MDP replotted and overlaid with Eqs. 1 (blue curve) and 2 (red curve) using N values of (A and B) 5, (C and D) 15, (E and F) 30, and (G and H) 100. In these simulations, ∆G^o = −5.7 RT and d = 8 nm which according to Eq. 2 gives F_o= −N∆G^o/d = 3N pN when N_AMD = N_MDP. The simulated time courses of state occupancies are in Fig. S5.

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