Stress-specific feedback loops control the attenuation of the heat shock response (HSR). Under basal conditions Hsp70 binds to Hsf1, preventing its binding to heat shock elements (HSEs). Activation: Diverse stress conditions cause protein misfolding and aggregation resulting in depletion of Hsp70 available for Hsf1 repression. Released Hsf1 binds to HSEs, triggering transcription of heat shock genes. These include the core feedback regulator Hsp70 as well as auxiliary factors. Attenuation: The diverse auxiliary feedback factors mediate and sense stress-specific repair. Thereby, they precisely adjust the timing of Hsp70 rebinding to Hsf1 and HSR inactivation.