Inhibition of sweating by CaTAr1. (A) GFP fluorescence in the mouse paw injected with CaTAr1 (right) compared with the contralateral paw (left) on the same animal. (B and C) Sweating was visualized using the iodine/starch technique in GFP- and in CatAr1-expressing paws. (D) Bar chart summarizing the sweating areas recorded after 15 min in control (GFP) and CaTAr1 expressing paws (n = 13–15; unpaired t test, P = 0.0074). (E) Cartoons illustrating the different phases of a typical agonist-driven Ca²⁺ release signal with (Ctr) or without SOCE. The activation state and localization of the Ca²⁺ effectors are shown for the different phases. (F) To scale illustration of the Ca²⁺ effectors involved in tunneling. For STIM1 only the domains with the atomic structure solved are shown. (G) To scale depiction of 5 Orai1 channels and clusters of 125 SERCAs each.