Figure S2.
Activation of lysosomal TRPML1 channels by synthetic agonists and oxidants in human endothelial cells. (A and B) Dose-dependent activation of whole-endolysosome ITRPML1 by ML-SA5 (A) and by ML-SA8 (B) in HUVECs. (C) Activation of whole-endolysosome ITRPML1 by chloramine-T (Ch-T, 100 μM) in TRPML1-transfected HUVECs.

Activation of lysosomal TRPML1 channels by synthetic agonists and oxidants in human endothelial cells. (A and B) Dose-dependent activation of whole-endolysosome ITRPML1 by ML-SA5 (A) and by ML-SA8 (B) in HUVECs. (C) Activation of whole-endolysosome ITRPML1 by chloramine-T (Ch-T, 100 μM) in TRPML1-transfected HUVECs.

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