Long-range tracing revealed the dissipation pattern of brain-derived Aβ in the retina. (A) Long-term observation timelines of fluorescently labeled human Aβ injected into the CM. (B and C) Representative images of long-term tracking of the optic nerve and retinal Aβ transport. (D) Statistical graphs of the fluorescence intensity in long-term tracing experiments after CM injection (n = 8). (E) Representative images of long-term tracking of Aβ transport in optic nerve meningeal lymphatics. (F) Statistical graphs of the fluorescence intensity within lymphatics in long-term tracing experiments (n = 8). Data are representative of two independent experiments. All data are presented as mean ± SEM.