c-Myc positive regulation of hTERT in EGFRm NSCLC cells. (A and B) IF detection of hTERT (A) or hTERT and c-Myc (B). The indicated cell lines were exposed to DMSO or 100 nM osimertinib for 24 h. (C) Osimertinib modulation of hTERT in EGFRm NSCLC cell lines expressing ectopic c-Myc or c-Myc (T58A) gene. The treatment condition was the same for Fig. 2 G. Source data are available for this figure: SourceData FS1.