SMARCA5 mediates proper genetic re-programming of activated B cells. (A) Scheme illustrating the experimental design. (B) Volcano plots showing differential gene expression in transferred B1-8hi B cells 5 days after immunization (n = 3–6; three independent experiments, adjusted P value <0.05, and log2 FC > 0.58 or less than −0.58; raw P values were adjusted for multiple testing using the procedure of Benjamini and Hochberg). (C) Heatmap of differentially expressed genes. (D) GO term biological pathway analysis of upregulated genes in control B1-8hi B cells. (E) GSEA analysis of differentially expressed genes. NES, normalized enrichment score; FDR, false discovery rate.
Figure 5.

SMARCA5 mediates proper genetic re-programming of activated B cells. (A) Scheme illustrating the experimental design. (B) Volcano plots showing differential gene expression in transferred B1-8hi B cells 5 days after immunization (n = 3–6; three independent experiments, adjusted P value <0.05, and log2 FC > 0.58 or less than −0.58; raw P values were adjusted for multiple testing using the procedure of Benjamini and Hochberg). (C) Heatmap of differentially expressed genes. (D) GO term biological pathway analysis of upregulated genes in control B1-8hi B cells. (E) GSEA analysis of differentially expressed genes. NES, normalized enrichment score; FDR, false discovery rate.

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