SETD1B is frequently mutated or depleted in FL and DLBCL. (A) Schematic overview illustrating SETD1B mutations in FL and DLBCL. The mutations span all functional domains of the protein, with a notable hotspot mutation resulting in a premature stop codon at amino acid 30 (H8Pfs*30). (B and C) (B) Oncoprint representation of an integrated annotation of somatic mutations and DNA copy-number changes of KMT2 family genes in 216 FL and (C) 248 DLBCL samples from MSK database. SETD1B mutations showed a propensity to co-occur with KMT2D mutations (FL, P = 0.008; DLBCL, P = 0.064). P values were calculated by two-sided Fisher Exact test. (D and E) (D) Oncoprint representation of an integrated annotation of somatic mutations and DNA copy-number changes of SETD1B and TP53 genes in 216 FL and (E) 248 DLBCL from MSK database. SETD1B mutations showed a trend (non-significant) to a mutual exclusive relationship with loss of TP53 (FL, P = 0.256; DLBCL, P = 0.126). P values were calculated by two-sided Fisher Exact test. All samples are arranged in columns with genes labeled along rows. Only samples with alterations are shown.