Figure 2.
![Ca2+-release dependence on levels of DHPR-activation. (A–D) Predicted time course of [Ca2+(t)]js and SR Ca2+-release flux (t) at the maximal level of DHPR-activation and when the percentage of cRyR1s with DHPR-activation-dependent reduction of inhibition at the I1 sites is decreased (B) to 50%, (C) to 30%, and (D) to 10%. The graded reduction of Ca2+ release when the fraction of DHPR-activated cRyR1s is decreased at lower levels of DHPR-activation shows that the regenerative Ca2+ release is under DHPR control and implicitly under voltage control.](https://cdn.rupress.org/rup/content_public/journal/jgp/156/10/10.1085_jgp.202213113/1/jgp_202213113_fig2.png?Expires=1767722658&Signature=tttoIwJWlPDqXLyNPPUqPeQHJHWL4T-uV6bzmbJZTPRnqdFE5d77IlI8-XMHTv~zAwWu4i1Ta2yunl0aCOLL7i41sGhZKMcvS~26AeAFjYwD98xuIgC0BrRYdVYJpkFKZRcm30lMf2W5yTnps01yFPggsPCLom3qXWWLlacHFzo~uEkn9R4YIZLo--hb5ug-N0pr36a9jnCgI8pjdOWZVVsH3lEkHTs2QEivWcky2VT~7TWBTeB7p8RXQixMKkwDKTf0NqwVvq5n9n8PVABrwEKmrujzvzvk53qPCa3GfZgoosjo9l86d8hW3dGPD7WrN7MrHk4FdVCQM0qs~8-PYQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Ca 2+ -release dependence on levels of DHPR-activation. (A–D) Predicted time course of [Ca2+(t)]js and SR Ca2+-release flux (t) at the maximal level of DHPR-activation and when the percentage of cRyR1s with DHPR-activation-dependent reduction of inhibition at the I1 sites is decreased (B) to 50%, (C) to 30%, and (D) to 10%. The graded reduction of Ca2+ release when the fraction of DHPR-activated cRyR1s is decreased at lower levels of DHPR-activation shows that the regenerative Ca2+ release is under DHPR control and implicitly under voltage control.