LTDs with multiple lipid binding regions. (A–F) (A–C) Spatial density maps of lipids and (D–F) corresponding solvation for each lipid in the multi-step iterative protocol for the (A and D) SMP domain of E-Syt2, (B and E) chorein motif of Atg2, and (C and F) chorein motif of Vps13. The protein is shown in purple; the averaged lipid density is in green.