Figure S3.
GrTX-SIA interacts with VSDII and VSDIV in NaV1.6. Shown are representative current traces of KV2.1/NaV1.6 VSDII (top) and KV2.1/NaV1.6 VSDIV (bottom) before (black; control) and during 1 µM GrTX-SIA application (red) for 4 min. Grey traces indicate recovery of ionic currents upon toxin washout with 50K solution. These data underscore the notion that GrTX-SIA inhibited the KV2.1/NaV1.6 VSDII chimera more slowly compared to KV2.1/NaV1.6 VSDIV. Moreover, current recovery was faster for the KV2.1/NaV1.6 VSDII chimera compared with KV2.1/NaV1.6 VSDIV.

GrTX-SIA interacts with VSDII and VSDIV in Na V 1.6. Shown are representative current traces of KV2.1/NaV1.6 VSDII (top) and KV2.1/NaV1.6 VSDIV (bottom) before (black; control) and during 1 µM GrTX-SIA application (red) for 4 min. Grey traces indicate recovery of ionic currents upon toxin washout with 50K solution. These data underscore the notion that GrTX-SIA inhibited the KV2.1/NaV1.6 VSDII chimera more slowly compared to KV2.1/NaV1.6 VSDIV. Moreover, current recovery was faster for the KV2.1/NaV1.6 VSDII chimera compared with KV2.1/NaV1.6 VSDIV.

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