Figure 2.
GrTX-SIA inhibits NaV1.6. (A–C) Representative current trace recorded at −20 mV (A), normalized conductance (G/Gmax)-voltage and channel availability (I/Imax) relationships (B), and recovery from inactivation (% rec; C) are shown before (black) and after (red) a 4-min incubation period with 1 μM GrTX-SIA. The holding potential was −90 mV with 5 s between depolarizing pulses (see Fig. S1). (D) Dose-response relationship, fitted with the Hill equation, of GrTX-SIA (concentration in nM) versus percentage of current remaining when measured at −10 mV. Circles represent mean ± SEM of n = 6 oocytes for 1 nM, 10 nM, 100 nM, and 1 µM, and n = 5 oocytes for 3 µM.

GrTX-SIA inhibits Na V 1.6. (A–C) Representative current trace recorded at −20 mV (A), normalized conductance (G/Gmax)-voltage and channel availability (I/Imax) relationships (B), and recovery from inactivation (% rec; C) are shown before (black) and after (red) a 4-min incubation period with 1 μM GrTX-SIA. The holding potential was −90 mV with 5 s between depolarizing pulses (see Fig. S1). (D) Dose-response relationship, fitted with the Hill equation, of GrTX-SIA (concentration in nM) versus percentage of current remaining when measured at −10 mV. Circles represent mean ± SEM of n = 6 oocytes for 1 nM, 10 nM, 100 nM, and 1 µM, and n = 5 oocytes for 3 µM.

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