ARSJ, a model of mislocalized secreted proteins is degraded by DPP and UBR proteins. Representative confocal images of mislocalized ΔSP mutant ARSJ-GFP expressed in the context of GPS in DPP, UBR or control KO cells. Scale bar = 20 μM. Green, ARSJ-GFP; red, DsRed uniformly expressed; and blue, nucleus (DAPI).