STAT3 GOF BM can exacerbate inflammation in WT mice, related to Fig. 4 . (A and B) (A) Peripheral blood and (B) skin donor engraftment 12 wk after transplant in NT mice, including Ly6G⁺ polymorphonuclear neutrophils (PMNs). (C) Ear thickness of untreated BM chimeras 12 wk after transplant. (D) Histological measurements from H&E sections of ear tissue of IMQ-treated WT → WT or STAT3 GOF → WT chimeras. Bars: mean ± SEM. Statistical significance determined by one-way ANOVA with Sidak’s multiple comparisons test (C) or unpaired two-tailed or Welch’s t test (D). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data represent four experiments with 8–12 mice per group.