Cell composition across tissue compartment BC patients. (A) Heatmap displaying the average expression per cluster of genes used for their annotation across the 22 clusters of integrated cells from blood, urine, and tumor. (B) UMAP of integrated PBMC, UDCs, and tumor cells split by tissue. (C) Boxplot of cluster frequencies between tissue across all patients. (D) Bar plots of cell composition across matched urine, tumor, and blood specimens for each patient. Wilcoxon tests were performed (P value: * <0.05, ** <0.01, *** <0.001, **** <0.0001).