A nicotinic agonist increased PSCs in SACs in young (P7–8) mice. (A and C) Responses to nicotine (left) and oxotremorine (right) in ON SACs (A) and OFF SACs (C). The open bar above the trace shows the timing of the nicotine application. The thick black bar shows the timing of the oxotremorine application. Thin black bars indicate the analysis time windows (20 s) of PSCs. (B and D) Summary of the effects of nicotine (left) and oxotremorine (Oxo, right) on the charge transfer of ON SACs (B: nicotine, P = 0.00484; Oxo, P = 0.276, n = 9 cells [two from sliced retinae, 7 from whole-mount retinae] of six mice) and OFF SACs (D: nicotine, P = 0.00733; Oxo, P = 0.604, n = 6 cells [all from the sliced retinae] of four mice). Ctrl, before drug application; nicotine, during the nicotine application; Oxo, during the oxotremorine application. A paired t-test was used. **P < 0.01. Nicotine and oxotremorine were applied to the same cell in the order of oxotremorine followed by nicotine. Recordings were performed on P7–8 mice.