Pattern of recirculation between the blood and the tumor according to cluster and clonotype size in the tumor. (A and B) Representation of the clonotype identified in the blood by their TCRβ (A) or TCRα (B) chains according to their number of read (Nread) detected in the bulk TCRseq (x axis) and plotted according to their clonal size in the tumor identified in single cells (y axis). Each clonotype is colored by its cluster of origin in the single-cell tumor scRNAseq. In each panel, the number of reads in the blood corresponding to the tumor singletons is split according to their cluster of origin in the tumor. The percentages indicated above the triangles on the left (tumor clonotypes not found in the blood) indicate the percentage of non-circulating clonotypes.