Microglial TNFα does not modulate locomotor activity and anxiety-like behaviors. (a) No significant differences were measured between tCTL and micTNFα-KO mice in the open-field test for the distance covered (two-tailed unpaired t test, t(35) = 1.533, P = 0.1324). (b and c) Time spent in the central zone (two-tailed unpaired t test, t(35) = 0.7278, P = 0.4716); and velocity (two-tailed unpaired t test, t(35) = 1.587, P = 0.1214). (a–c)n = 17 tCTL and 20 micTNFα-KO mice. Data are expressed as means ± SEM.