Clogger removal from mitochondrial import channels in mammals and yeast. Molecules involved in clogger removal and representative cloggers utilized in each pathway are shown. The mammalian version of clogger developed by Krakowczyk et al. (2) is integrated in the IMM component, ATP synthase, upon clogging at the TOM translocase. In this pathway, the clogger is first cleaved by OMA1 upon mitochondrial depolarization, which promotes the clogger release from the TOM translocase. In all reported pathways, cloggers are degraded by proteasome. OMM, outer mitochondrial membrane; IMM, inner mitochondrial membrane; MTS, mitochondrial targeting sequence; DHFR, dihydrofolate reductase; HB, haem-binding domain.